• 1983: Foundation of Aviation Sans Frontières Belgium (ASF-B).
• 1984-1988: Mali - ASF-B offers its services to several NGOs during major famines in the Sahel and actively participates in the fight against cholera.
• 1985-1988: Ethiopia - ASF-B organises the transportation of humanitarian staff and material during large famines.
• 1985-1987: Chad - ASF-B enables Médecins Sans Frontières (MSF) to extend its programmes into the north of Chad and transport medicine products, doctors, nurses and mobile surgical teams to the humanitarian aid sites. ASF-B offers air support to the national vaccination campaigns.
• 1985: Sudan - ASF-B transports humanitarian aid to refugees from Chad along the Sudanese border.

 

• 1987-1991: Mozambique - ASF-B assists Médecins Sans Frontières (MSF) and Save the Children. Its aircraft allows them to reach villages surrounded by the guerrillas and, thanks to its action, the national healthcare structures were able to reorganise and eradicate major epidemics.
• 1988: Zaire - ASF-B repairs bush runways to facilitate access to isolated groups.
• 1988-1994: Ecuador - ASF-B develops an air ambulance programme in the province of Pastora, funded by the Belgian Development Cooperation. ASF-B buys two Cessna 206, and trains national pilots and mechanics.
• 1994-1995: Great Lakes Region (Rwanda - Burundi - Tanzania) - ASF-B organises an air bridge to bring assistance to refugee and displaced groups from Burundi.
• 1995-1996: Sierra Leone - ASF-B organises an air bridge between Bo and Potjahum to allow Médecins sans Frontières to implement emergency relief. In full-on civil war, the ASF-B aircraft becomes the last resort for humanitarian operators to evacuate their humanitarian aid sites.

 

• 1997-2002: Democratic Republic of the Congo - ASF-B ensures the distribution of medicines in bush healthcare centres for the Archdiocese of Kisangani. ASF-B then flies for multiple NGOs such as: MSF, CICR, Unicef, Merlin, Médair. From January 1999, ASF-B operates exclusively with MSF in the rebel zone to distribute medicines, supply nutritional centres and becomes an essential tool of the Congo Emergency Pool (PUC) responsible for the detection and eradication of epidemics. 
• 2000-2004: Mali - ASF-B participates in consolidating peace agreements by making an aircraft available to around 60 NGOs. In addition to its work in opening up northern Mali, ASF-B helps improve security, increases the performance of technical staff and encourages the continuation of their programmes even during the rainy period, a period normally synonymous with isolation.
• 2003-2009: Democratic Republic of the Congo - The humanitarian air support programme in Ituri implemented by ASF-B and jointly funded with UNOCHA aims to allow humanitarian stakeholders operating in Ituri and surrounding regions to have a quick and secure means of transport for staff and humanitarian material, and to expand the humanitarian intervention areas. From 1 February 2005, the European Commission Humanitarian Aid and Civil Protection Office (ECHO) continued joint funding of operations in Ituri. The mission ended in March 2009.
• 2005-2007: Somalia - In a context of humanitarian emergency, on 16 May 2005 ASF-B began under ECHO funding an air transport programme for the ECHO partners and all humanitarian stakeholders operating in Somalia. The goal of this ASF-B programme is to allow groups in Somalia to benefit from the application of the humanitarian and development stakeholders’ mandate and, specifically, to strengthen access through regular air links financed by ECHO.
• 2006-2009: Kenya - In the wake of humanitarian air operations launched in Somalia, ASF-B implemented an air transport programme for ECHO partners in North and East Kenya first, which was subsequently extended throughout the country depending on humanitarian emergencies and to pass on the baton to the ECHO Flight in March 2009. 
• 2007-2008: Democratic Republic of the Congo – Like its mission in Ituri, and this time financed by the United Nations Development Programme (UNDP), ASF-B placed a Cessna 206 in Kisangani to allow humanitarian stakeholders operating in the region to have a quick and safe means of transport for humanitarian personnel and material, and to expand the area of intervention.
• Since 2008: Madagascar (environment) – Launch of a Mission supporting conservation and good biodiversity management in Madagascar, in the context of increasing deforestation. ASF-B links with WWF to complete flights and take aerial photographs in order to better understand the areas at risk. The approach pursued in the development of this aerial monitoring tool of the forest is based entirely on a sustainable development approach and won the Belgian Energy and Environment Award 2012. 
• 2010-2011: Democratic Republic of the Congo - The main objective of the mission supporting conservation and good biodiversity management in DRC open in Mbandaka was to open up the largest national forestry park in Africa, the Salonga. ASF-B flights help support WWF and African Wildlife Foundation operations and the European Commission programme to manage Forest Ecosystems in Central Africa (ECOFAC). A second mission was opened in Goma supported by the German Technical Cooperation (GIZ) and the Congo Institution for Nature Conservation (ICCN) for the Kahuzi-Biega National Park. 
• 2008-2013: Chad - Following rebel attacks at the end of 2007 in the east of Chad, which destabilised the humanitarian mechanism implemented by the international community to assist refugees from Darfur and internally displaced groups, ASF-B located two of its Cessna 206 in Abéché to provide NGOs and United Nations agencies the flexibility desired for their operations in an environment characterised by constant insecurity. This was in perfect harmony with the regular air service provided by UNHAS (United Nations Humanitarian Air Services). 
• 2014-2015: Central African Republic – The Central African Republic (CAR) is on the edge of total collapse. An unprecedented increase in violence accelerated the disintegration of the State that began in 2012 under the rebel attack coup, thus bringing a population of 4.6 million people into arbitrariness, violence, looting and assassinations. In order to bring back a little bit of humanity into this chaos, ASF-B operated a Cessna 206 in Bangui using its own funds for seven months to support NGOs. This was done with the financial and operational support of the Netherlands and United Kingdom branches of the ASF. This mission succeeded once again in showing the existence of additional air transport needs in relation to the mechanism put in place by the United Nations.
• 2015-2016: Madagascar (humanitarian) – Engaged in the fight for environmental protection in Madagascar, ASF-B could not remain indifferent to the structural humanitarian crisis affecting its project area in the south of the country, where child nutrition indicators are dangerously poor with one of the five highest malnutrition rates in the world. ASF-B identified NGOs working on the ground and began to support them through humanitarian flights due to the increasing insecurity on and poor condition of the road infrastructure. 
• 2016 to date: Madagascar (Humanitarian) – Aviation Sans Frontières – Belgium (ASF-B), engaged in the fight for environmental protection in Madagascar, cannot remain indifferent to the structural humanitarian crisis in its project area in the south of the country. In this region, the nutrition indicators for children are in the red and are one of the five highest figures of malnutrition in the world.  In view of this, ASF-B decided in 2016 to provide air and logistical support to the French NGO Médicaéro for its air medicine project. This project involves flying a multidisciplinary medical team directly to patients in remote areas of the Ampanihy district, in southwestern Madagascar. The NGO Médicaéro teams conduct quarterly site visits to support the local teams.  The project includes consultations, nursing, exchange of experience and strengthening the capacity of the local staff, practical education for medical students, the allocation of medicines for health centers and surgical interventions.